Shasta Oligo Synthesizer

Shasta Oligo Synthesizer

The Shasta Synthesizer is a cutting-edge solution designed for high-output laboratories seeking unparalleled flexibility, reliability, and efficiency in oligonucleotide production. Engineered with patented hardware and intuitive software, it delivers superior yields, faster turnarounds, and reduced labor through enhanced coupling efficiency and minimal reagent waste. Its scalable design seamlessly supports applications from small-scale assays to large-scale 100umol+ synthesis, eliminating the need for multiple systems. With ready-made protocols, robust safety certifications, and a unified platform for ultra-high throughput screening and custom method development, the Shasta ensures precision, scalability, and streamlined workflows for labs aiming to optimize performance.

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Description

The Shasta Synthesizer – Ultra-Efficient Oligo Production That Scales

The Shasta Synthesizer is engineered for high-output labs demanding flexibility, reliability, and minimal downtime. Its patented hardware, user-friendly software, and robust safety certifications reduce labor and deliver higher yields with faster turnarounds. The Shasta supports applications from high-throughput screening to large-scale production.

Key Features

Scalable Design: Adapts to small-scale assays or 100umol+ scale oligo production, growing with your lab’s needs.
Unified Platform: Supports ultra-high throughput screening, custom method development, and large-scale synthesis without protocol migration.
Enhanced Efficiency: Patented technology boosts coupling efficiency, minimizing reagent waste and maximizing output.
Intuitive Software: Streamlines workflow management, reducing manual intervention and errors.
Stock Protocols: Ready-made protocols to get you started on day one.
Safety Certified: Meets rigorous lab standards for reliable, secure operation.

The Shasta Synthesizer eliminates the need for multiple systems, providing a single, versatile solution for high-throughput labs aiming for precision, scalability, and speed.

Patented Selective Drain System – Speed Meets Control

Unlike alternative systems, Shasta’s Selective Drain System allows users to:

  • Drain rows or columns individually
  • Skip finished wells—no wasted reagents due to sequence variability
  • Minimize drain times by isolating only what’s needed

The result: shorter runs, reduced solvent usage, and greater consistency.

Standard Features

  • 24 Amidite + 8 Reagent Positions
  • Kalrez® & PTFE seals throughout
  • Full Software with No License Fees
  • Up to 10 Backbone Modifications
  • Amidite-Specific Handling
  • Includes installation, training, and 1-year warranty

Approvals

  • UL 61010-1
  • cUL 61010-1-12
  • CE, EMC Directive 2014/30/EU
  • CE, LVD Directive 2014/35/EU

White Paper

768 Module – For the Highest Throughput Needs

The Shasta 768 module is designed for high-throughput applications, ideal for scientists conducting oligo screening, library generation, or custom batch synthesis. It accommodates one or two 384-well plates, and supports extensive oligonucleotide synthesis applications.

Key Features:

  • Up to 768 samples for maximum throughput
  • 2–200 nmol synthesis scale for flexible experiment design
  • 16 unique protocols with 48 replicates each, supporting diverse workflows
  • Ensures efficiency and precision for demanding laboratory needs.

Shasta Photos

Additional information

Shasta Model

64, 192, 768