K&A Oligo Synthesizer

K&A Oligo Synthesizer

The K&A Synthesizer is a versatile and powerful tool designed for laboratories requiring precision and adaptability in solid-phase synthesis. Supporting universal, standard, and modified resins, it offers variable synthesis scales up to 10 µmol, with fully programmable synthesis control and flexible, user-modifiable port assignments. Its advanced capabilities include compatibility with over 10 backbone modifications and mixed-base coupling, ensuring seamless integration with all solid-phase synthesis methods. This robust platform empowers labs to achieve high precision and efficiency, streamlining workflows across diverse applications.

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Description

Core Features Across All Models

  • Accepts universal, standard, and modified resins
  • Variable synthesis scales up to 10 µmol
  • Fully programmable synthesis control
  • Flexible, user-modifiable port assignments
  • Supports 10+ backbone modifications
  • Mixed-base coupling capability
  • Compatible with all solid-phase synthesis methods

The Smallest Oligo Synthesizer in the World

S-4-LC Oligo SynthesizerThe K&A S-4-LC is the world’s smallest DNA/RNA/LNA synthesizer—ideal for research labs that need rapid oligo production without sacrificing valuable bench space.

  • 4 Column Positions
  • 16 Bottle Positions
  • Cycle time 2½ – 3 minutes for a full 4 column synthesis
  • Dimensions (WxHxD): 25 x 25 x 30 cm
  • Does not include trityl monitor

Minimal Consumption, Maximum Efficiency

K&A H2 Oligo Synthesizer

The H-2 delivers the full feature set of the H-8 with fewer active column positions, making it ideal for applications that don’t require high-throughput synthesis. Designed as a seamless replacement for the ABI 392 or Expedite, it offers reliable performance while minimizing reagent use and waste.

  • 2 columns
  • 14 bottle positions
  • Cycle time 2 – 2 ½ minutes for 2 column synthesis
  • Online trityl monitor for all columns (all trityl collected)
  • Dimensions (WxHxD): 25 x 40 x 40 cm

Large Scales, Small Footprint

K&A H4-VLS Oligo SynthesizerThe H-4-VLS is a modified H-8, engineered for synthesis scales exceeding 100 µmol—perfect for applications that require higher sample yields per run.

  • 4 columns with double-spacing to allow for larger columns
  • 18 bottle positions
  • Variable synthesis scale up to 100+ µmol
  • Online trityl monitor for all columns (all trityl collected)
  • Dimensions (WxHxD): 25 x 40 x 40 cm

Premium Oligo Synthesizer

K&A H8 Oligo SynthesizerThe H-8 represents the culmination of years of synthesis engineering, refined for modern research. Our flagship closed-column synthesizer delivers high-purity, long oligo synthesis.

  • 8 columns
  • 14 bottle positions
  • Cycle time 4 – 4 ½ minutes for 8 column synthesis
  • Online trityl monitor for all columns (all trityl collected)
  • Dimensions (WxHxD): 25 x 40 x 40 cm

Every Modification Possible

K&A H8-SE Oligo SynthesizerBuilding on the popular H-8, the H-8 SE offers expanded flexibility for researchers experimenting with a wide variety of amidites and reagents.

  • 8 columns
  • 30 bottle positions
  • Online trityl monitor for all columns (all trityl collected)
  • Dimensions: 25cm x 60cm x 40cm

Large Scales in Throughput

K&A H8-VLS Oligo SynthesizerThe H-8-VLS is an H-8 SE variant capable of synthesis scales up to 100 µmol and beyond. Built for researchers who require maximum flexibility, it combines expanded capacity with all the core features of the H-8 SE:

  • 8 columns
  • 30 bottle positions
  • Variable synthesis scale up to 100+ µmol
  • Online trityl monitor for all columns (all trityl collected)
  • Dimensions: 35 x 60 x 40 cm

Throughput Expansion

K&A H16 Oligo SynthesizerThe H-16 retains the compact footprint of the H-8 SE while adding 8 column positions in place of 8 bottle positions.

  • 16 columns
  • 22 bottle positions
  • Online trityl monitor for all columns (all trityl collected)
  • Dimensions: 35 x 60 x 40 cm

A Freely Programmable Synthesizer

K&A H32 Oligo SynthesizerThe H-32 retains all the features of its predecessors while scaling up to meet the demands of high-production facilities.

Its fully programmable delivery system allows users to exchange all columns for amidites or reagents, providing maximum flexibility and control.

  • 32 column positions
  • 11 positions
  • Online trityl monitor for all columns (all trityl collected)
  • Dimensions (WxHxD): 35 x 65 x 45 cm

K&A Photos

Additional information

K&A Model

S-4-LC, H-2, H-4-VLS, H-8, H-8-SE, H-8-VLS, H-16, H-32